Cardiac magnetic resonance multi-parameter imaging was used to evaluate left ventricular function and myocardial stress in patients with hypertrophic cardiomyopathy. A series of multiparametric magnetic resonance imaging was performed on 34 patients with asymmetrical hypertrophic cardiomyopathy diagnosed by MRI, using CVI software. Cardiac function was detected, and 322 hypertrophic myocardial segments and 222 non-hypertrophic segments were characterized for post-tracking. According to the American Heart Association 17-segment rule, the strain parameters and left ventricle of 16 segments except the apex were measured. The overall strain parameters preliminarily concluded that the left ventricular global stress of patients with hypertrophic cardiomyopathy was lower than that of normal people; the peak radial strain, peak long axis strain, peak circumferential strain and peak diameter of hypertrophic myocardial segments in patients with hypertrophic cardiomyopathy The strain rate and peak circumferential strain rate were significantly lower than the non-hypertrophic myocardial segments.