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Abstract #2185

Regional Heterogeneity of Errors in Myocardial Perfusion Quantification Using Bolus-Based MRI

Johannes Martens1, Sabine Panzer1, Jeroen P. H. M. van den Wijngaard2, Maria Siebes2, and Laura Maria Schreiber1

1Chair of Cellular and Molecular Imaging, Comprehensive Heart Failure Center, University Hospital Wuerzburg, Wuerzburg, Germany, 2Dept. of Biomedical Engineering & Physics, Academic Medical Center, Amsterdam, Netherlands

Aim of the project is the computational modeling of contrast agent dispersion in coronary arteries down to pre-arteriolar level during contrast-enhanced MRI myocardial perfusion measurements. From a high resolution imaging cryomicrotome dataset a vascular 3D model of the left main coronary artery is extracted and furnished with a computational grid. Using an advanced boundary condition, Navier-Stokes equations for blood flow and the advection-diffusion equation for CA transport are solved to obtain CA bolus dispersion values on this model of unprecedented detail, and to analyze myocardial blood flow quantification errors. The analysis of the obtained results shows strong variability on the cm-scale.

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