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Abstract #2186

Altered myocardial velocities and stress perfusion in heart transplant patients affected by coronary allograft vasculopathy

Roberto Sarnari1, Muhannad Abbasi 1, Arif Jivan 1, Rahim Gulamali1, Alexander Ruh1, Julie Anne Blaisdell1, Brandon Clifford Benefield1, Ryan Dolan1, Kambiz Ghafourian1, Jane Wilcox1, Sadiya Sana Khan1, Esther Vorovich1, Jonathan Rich1, Allen Anderson1, Clyde Yancy1, James Carr1, Daniel Lee1, and Michael Markl1

1Northwestern University, Chicago, IL, United States

Coronary allograft vasculopathy (CAV) is responsible for long term mortality after heart transplant (HTx). Myocardial perfusion impairment resulting from CAV can lead to early graft dysfunction. Our study aimed to quantify perfusion and 3-directional myocardial velocities by cardiac magnetic resonance perfusion and tissue phase mapping (TPM) sequences and describe the relationship at global and segmental level. Thirty two HTx patients affected by CAV were analyzed. Myocardial perfusion reserve was reduced in CAV patients and associated with reduced left ventricular twist during contraction. LV diastolic radial velocities and interventricular synchrony were associated as to rest and to stress myocardial perfusion variations

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