Abstract #2216

Pulmonary circulation time measurements and lung blood volume estimation in mice by magnetic particle imaging and magnetic resonance imaging

Michael Gerhard Kaul¹, Johannes Salamon¹, Caroline Jung¹, Matthias Graeser^2,3, Harald Ittrich¹, Gerhard Adam¹, and Kersten Peldschus¹

¹Department for Interventional and Diagnistic Radiology and Nuclear Medicine, University Medical Center Hamburg, Hamburg, Germany, ²Section for Biomedical Imaging, University Medical Center Hamburg, Hamburg, Germany, ³Institute for Biomedical Imaging, Hamburg University of Technology, Hamburg, Germany

Pulmonary circulation time and/or the blood volume of the lungs can be used to depict pathologic changes. The purpose of our study was to determine the circulation time of a bolus of superparamagnetic iron oxide nanoparticles through the lungs by MPI and to estimate the blood volume of the lungs supplemented by cardiac MRI. The pulmonary circulation times were 907 ± 141 ms. The determination of the blood volume revealed a volume of 233 ± 48 µL.

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