This study aims to investigate the feasibility and efficacy of a closed-chest method for coronary stenosis creation in swine models of ischemic heart disease (IHD). We successfully deployed high-resolution 3D printed intracoronary implants in three healthy swine subjects using a transcatheter angioplasty delivery approach. All subjects underwent angiography and MR cine imaging for assessment of ventricular regional wall motion. At post-mortem dissection, we successfully retrieved the implants. These results support early feasibility and efficacy of our proposed approach for applications including stress testing, infarct creation, and evaluation of diagnostic techniques or therapeutics in swine models of IHD.