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Abstract #2218

Cardioprotective Effects of Mild Therapeutic Hypothermia in Hemorrhagic Myocardial Infarctions: Early Findings in a Swine Model of Acute Reperfused Myocardial Infarction

Eric Andrew Johnson1,2, Guan Wang1, Richard Tang1, Behzad Sharif1, Ivan Cokic1, Andreas Kumar3, and Rohan Dharmakumar1,2

1Cedars Sinai, Los Angeles, CA, United States, 2UCLA, Los Angeles, CA, United States, 3Northern Ontario School of Medicine, Thunder Bay, ON, Canada

Patients who experience hemorrhagic myocardial infarctions (hMIs) have increased risk of adverse outcomes, yet a protective therapy remains to be developed. We hypothesized that mild hypothermia to the heart can reduce the effects of hemorrhage and improve left ventricular functional recovery in the setting of reperfused infarctions. This was studied using a swine model of hemorrhagic infarction exposed to cooled pericardial saline infusion to confer hypothermia. Results show a significant decrease in hemorrhagic remnants and increase in LVEF for the hypothermia group relative to controls at 1 month post-MI. Therapeutic cooling has the potential to offer cardioprotective benefits for hMI.

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