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Abstract #2226

A Universal Edited MRS Sequence for 4 Vendors

Muhammad G Saleh1,2, Daniel Rimbault3, Mark Mikkelsen1,2, Georg Oeltzschner1,2, Anna M Wang1,2, Dengrong Jiang1, Ali Alhamud3,4, Jamie Near5, Michael Schär1, Ralph Noeske6, James B Murdoch7, Lars Ersland8,9,10, Alexander R Craven8,9, Gerard Eric Dwyer8,9, Eli Renate Gruner8,9, Li Pan11, Sinyeob Ahn12, and Richard A Edden1,2

1Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Medical Imaging Research Unit, Division of Biomedical Engineering, University of Cape Town, Cape Town, South Africa, 4University of Tripoli, Tripoli, Libyan, 5Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, QC, Canada, 6GE Healthcare, Berlin, Germany, 7Canon Medical Research USA, Cleveland, OH, United States, 8Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway, 9Norwegian Center for Mental Disorders Research, University of Bergen, Bergen, Norway, 10Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway, 11Siemens Healthineers, Baltimore, MD, United States, 12Siemens Healthineers, San Francisco, CA, United States

MEGA-PRESS is the most widely used pulse sequence for edited MRS of low-concentration metabolites, e.g. GABA, glutathione and lactate. However, current implementations of MEGA-PRESS are diverse across MR vendors, leading to differences in the shape and intensity of the final edited signal. We demonstrate a new universal editing sequence (with MEGA and HERMES functionality) for the major MR vendor platforms with standardized RF pulse shapes, durations, amplitudes and sequence timings. Phantom and in vivo experiments show excellent agreement among vendors, including consistency in lineshape and reduced variation in concentration measurements.

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