Abstract #2226

A Universal Edited MRS Sequence for 4 Vendors

Muhammad G Saleh^1,2, Daniel Rimbault³, Mark Mikkelsen^1,2, Georg Oeltzschner^1,2, Anna M Wang^1,2, Dengrong Jiang¹, Ali Alhamud^3,4, Jamie Near⁵, Michael Schär¹, Ralph Noeske⁶, James B Murdoch⁷, Lars Ersland^8,9,10, Alexander R Craven^8,9, Gerard Eric Dwyer^8,9, Eli Renate Gruner^8,9, Li Pan¹¹, Sinyeob Ahn¹², and Richard A Edden^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Medical Imaging Research Unit, Division of Biomedical Engineering, University of Cape Town, Cape Town, South Africa, ⁴University of Tripoli, Tripoli, Libyan, ⁵Douglas Mental Health University Institute and Department of Psychiatry, McGill University, Montreal, QC, Canada, ⁶GE Healthcare, Berlin, Germany, ⁷Canon Medical Research USA, Cleveland, OH, United States, ⁸Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway, ⁹Norwegian Center for Mental Disorders Research, University of Bergen, Bergen, Norway, ¹⁰Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway, ¹¹Siemens Healthineers, Baltimore, MD, United States, ¹²Siemens Healthineers, San Francisco, CA, United States

MEGA-PRESS is the most widely used pulse sequence for edited MRS of low-concentration metabolites, e.g. GABA, glutathione and lactate. However, current implementations of MEGA-PRESS are diverse across MR vendors, leading to differences in the shape and intensity of the final edited signal. We demonstrate a new universal editing sequence (with MEGA and HERMES functionality) for the major MR vendor platforms with standardized RF pulse shapes, durations, amplitudes and sequence timings. Phantom and in vivo experiments show excellent agreement among vendors, including consistency in lineshape and reduced variation in concentration measurements.

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