Abstract #2227

Simultaneous edited detection of GABA, glutathione and ethanol using HERMES

Muhammad Saleh^1,2, Anna M Wang^1,2, Mark Mikkelsen^1,2, Georg Oeltzschner^1,2, Eric C Porges ^3,4, and Richard A Edden^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, United States, ⁴Center For Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, United States

HERMES allows simultaneous edited detection of multiple low-concentration metabolites in the human brain. Here, HERMES editing of GABA, glutathione (GSH) and ethanol (EtOH) is demonstrated for the investigation of the effects of acute administration of EtOH on the human brain. Simulations and phantom experiments demonstrate excellent detection and separation of GABA, GSH and EtOH. In vivo data were acquired in a healthy male volunteer after oral administration of alcohol. Data were continuously acquired for 1 h and broken down into successive 4-min blocks, showing increasing levels of brain EtOH throughout the scan session.

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