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Abstract #2233

Functional magnetic resonance spectroscopy towards detection of initiated release of GABA in chemogenetically modified mice

Inbar Zohar1, Inbar saraf-sinik2, Ofer Yizhar2, and Assaf Tal1

1Biological and Chemical Physics, Weizmann Institute of Science, Rehovot, Israel, 2Neurobiology, Weizmann Institute of Science, Rehovot, Israel

Dynamics of γ -aminobutyric acid (GABA) concentrations in the brain has been shown to vary under a variety of activation paradigms using functional magnetic resonance spectroscopy (fMRS). To provide better understanding of the underlying cellular mechanisms involved, we used fMRS on chemogenetically engineered mice at ultrahigh fields (15.2T), allowing us to investigate the dynamics of metabolites in response to activation of a specific neuronal population (GABAergic) in the reticular nucleus. fMRS data from four mice was analyzed using LCModel and did not show any significant change in GABA.

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