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Abstract #2234

Reliability of in vivo Glx measurements from GABA-edited MRS at 3T

Tiffany Kay Bell1,2,3, Elodie S Boudes1,2,3, Rachelle S Loo1,2,3, Gareth J Barker4, David J Lythgoe4, Richard AE Edden5,6, R Marc Lebel7, Martin P Wilson8, and Ashley D Harris1,2,3

1Department of Radiology, University of Calgary, Calgary, AB, Canada, 2Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, 3Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada, 4Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom, 5Russel H Morgan Department of Radiology, The Johns Hopkins School of Medicine, Baltimore, MD, United States, 6F.M. Kirby Centre for Functional MRI, Kennedy Krieger Institute, Baltimore, MD, United States, 7General Electric Healthcare, Calgary, AB, Canada, 8School of Psychology, University of Birmingham, Birmingham, United Kingdom

To measure glutamate and GABA, two spectroscopy sequences are typically performed. Here we investigate the reliability of measuring Glx (glutamate+glutamine) from the same editing sequence used to measure GABA (MEGA-PRESS). We found that Glx measured using the unedited (“off”) sub-spectra of a macromolecule suppressed MEGA-PRESS sequence (MM-suppressed, TE=80ms) moderately agreed with Glx measured using a short-echo PRESS sequence. However, Glx measured using the off sub-spectra of a GABA+ (TE=68ms) MEGA-PRESS sequence and the co-edited Glx signal from the difference spectra of both GABA-edited MEGA-PRESS sequences showed poor agreement.

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