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Abstract #2238

Localised 2D J-resolved spectroscopy: Enhanced sensitivity and accelerated acquisition of brain metabolites

Christopher Wickens1, Stephen J Sawiak1, Keri L.H Carpenter2, Adrian T Carpenter1, and Christopher T Rodgers1

1Wolfson Brain Imaging Centre, University of Cambridge, UK, CAMBRIDGE, United Kingdom, 2The Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom

Proton 1D MR spectroscopy has been used to quantify alterations in cerebral metabolite concentrations to investigate neurological diseases. However, the J-coupling found in key metabolites produce multiplets which result in highly overlapped signals, complicating signal quantification. 2D J-resolved spectroscopy (JPRESS) allows distribution of coupled signals into a second perpendicular dimension, reducing signal overlap. Unfortunately, the translation of 2D-JPRESS into a commonly used clinical tool has not been achieved due to limited post-processing strategies and long scan times. Here, a simple processing strategy to significantly enhance signal sensitivity and a technique to accelerate JPRESS by 30% are presented.

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