Abstract #2239

Longitudinal relaxation times of macromolecules and their suppression in MEGA-PRESS 1H-MR-brain spectra at 3 T

Andreas Masek¹, Alexander Gussew¹, and Jürgen R Reichenbach^1,2,3,4

¹Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany, ²Michael Stifel Center for Data-driven and Simulation Science Jena, Jena, Germany, ³Abbe School of Photonics, Jena, Germany, ⁴Center of Medical Optics and Photonics, Jena, Germany

Taking advantage of the adiabatic inversion based macromolecule (MM) suppression approach, the MM contamination of the neurotransmitter GABA can be significantly reduced in MEGA-PRESS ¹H-MR brain spectra. In this work, the longitudinal relaxation times (T₁) of brain macromolecules were determined in posterior cortex of healthy subjects in order to adjust the inversion delays for MEGA-PRESS based measurements of pure GABA. Compared to main brain metabolites, T₁ times of MMs are significantly shorter and further reveal a very low inter-individual variation, which allows us to use the MM nulling approach without substantial T₁ weighing related attenuations of metabolite signals and further to apply fixed TI settings instead of performing individual T₁ measurements in future studies.

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