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Abstract #2240

Quantification of Glutamate/Glutamine using LCModel for MEGA-PRESS sequence at 3 T

Hu Cheng1 and Sharlene Newman1

1Psychological and Brain Sciences, Indiana University, Bloomington, IN, United States

We conducted a Monte-Carlo simulation to investigate the quantification of glutamate (Glu) and glutamine (Gln) using MEGA-PRESS and LCModel at 3 T. The results demonstrate that both glutamate and glutamine can be reliably quantified along with Gamma-aminobutyric acid if the spectrum linewidth is smaller than 0.06 ppm. However, our in vivo results showed a higher ratio of Glu/Gln, which is out of the physiological range measured by other methods. Our work suggests that glutamate and glutamine can be quantified at high accuracy in theory but the accuracy might be compromised in practice by other factors that affects the spectrum quality.

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