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Abstract #2241

A pilot study on the GABA+ level in midbrain of healthy volunteers using MEGA-PRESS technique

Yulu Song1, Tao Gong1, Fei Gao1, Richard A.E. Edden2, Weibo Chen3, and Guangbin Wang1

1Shandong Medical Imaging Research Institute, Jinan, China, 2The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Philips Healthcare, Shanghai, China

Gamma-aminobutyric acid (GABA) in midbrain is insignificant to be measured. To determine the GABA+ level, we employed Mescher-Garwood point-resolved spectroscopy (MEGA-PRESS) by a small region of interest (ROI)(1.0 × 2.5 × 3.0 cm), which is a new technique that could precisely measure the level of the inhibitory neurotransmitter. The distribution is 2.47 ±0.66 (χ±SD),and it is prove that there was no correlation of GABA+ level with age in healthy volunteers.

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