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Abstract #2245

What are the effects of adding macromolecules to the basis set on metabolite quantification reproducibility and accuracy? A comparison of different macromolecular models for FID-MRSI in the brain at 7T

Eva Heckova1, Michal Považan2, Bernhard Strasser3, Stanislav Motyka1, Gilbert Hangel1, Lukas Hingerl1, Philipp Moser1, Stephan Gruber1, Siegfried Trattnig1,4, and Wolfgang Bogner1,4

1High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2Russell H. Morgan Department of Radiology and Radiological Science, The John Hopkins University School of Medicine, Baltimore, MD, United States, 3Athinoula A. Martinos Center for Biomedical Imaging,Department of Radiololy, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, 4Christian Doppler Laboratory for Clinical Molecular Imaging, Vienna, Austria

This work investigates the influence of different macromolecular baseline models on the reliability and test-retest reproducibility of metabolite quantification for clinically attractive ~5min 2D-FID-MRSI with nominal voxel volume 3.4×3.4×8mm3. We confirmed that FID-MRSI with adequate MM prior knowledge provides highly reproducible (CV<11%) and reliable results (ICC>0.75) for the common metabolites even when using more flexible parameterized MM models.

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