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Abstract #2246

An Analysis of 1H Metabolite Residuals in an Acquired Macromolecule Spectrum

David McAllindon1,2, Chris Bowen2,3,4, Denise Bernier1,5, and Philip G Tibbo1,5

1Psychiatry, Dalhousie University, Halifax, NS, Canada, 2Biomedical Translational Imaging Center, IWK Health Center, Halifax, NS, Canada, 3Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Canada, 4Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada, 5Nova Scotia Early Psychosis Program, Nova Scotia Health Authority, Halifax, NS, Canada

Macromolecules underly the metabolites in short-TE 1H magnetic resonance spectroscopy and must be accounted for in a quantitative analysis. One method is to acquire a metabolite-nulled spectrum and use it to account for macromolecules in fitting; however, since metabolites have a range of T1, metabolite-nulling is incomplete and leaves residuals. We introduce a new metabolite cleaning method with 2 metabolite-nulling schemes, single inversion and double inversion, and use it to examine the estimated metabolite residuals, finding that even with double-inversion nulling, there are substantial metabolite residuals of 10-35% in the macromolecule spectrum.

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