Macromolecules underly the metabolites in short-TE 1H magnetic resonance spectroscopy and must be accounted for in a quantitative analysis. One method is to acquire a metabolite-nulled spectrum and use it to account for macromolecules in fitting; however, since metabolites have a range of T1, metabolite-nulling is incomplete and leaves residuals. We introduce a new metabolite cleaning method with 2 metabolite-nulling schemes, single inversion and double inversion, and use it to examine the estimated metabolite residuals, finding that even with double-inversion nulling, there are substantial metabolite residuals of 10-35% in the macromolecule spectrum.
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