In short echo time spectroscopy sequences macromolecular signals may strongly influence the quantification of metabolite spectra they underlay. In this work we present a method for simulating a MM basis set that is tailored toward chosen sequences and sequence parameters with the aim to improve the accuracy of metabolite measurements in vivo. We show that utilizing a simulated macromolecule basis set while considering the relaxation behavior of individual macromolecular resonances can produce metabolite quantification results of similar quality to that of a dedicatedly measured MM basis set when applied to the same spectra of interest.
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