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Abstract #2249

Low Reliability between in vivo Measurements of Glutamatergic Metabolite Concentrations in Two Proton MR Spectroscopy Sequences

Charles P. Lewis1, Paul A. Nakonezny2, Mark A. Frye1, Balwinder Singh1, Paul E. Croarkin1, and John D. Port1,3

1Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, United States, 2Department of Clinical Sciences, Division of Biostatistics, UT Southwestern Medical Center, Dallas, TX, United States, 3Department of Radiology, Mayo Clinic, Rochester, MN, United States

Newer spectral sequences have been developed to focus quantification of specific metabolites. In this study, measurements of glutamatergic metabolites in a human sample (N=178) were compared between two sequences, a standard TE-optimized PRESS sequence designed to capture broad spectral resonance and a 2-dimensional J-resolved PRESS sequence developed specifically for glutamate signal acquisition at the expense of broad resonance capability. Cho/Cr and NAA/Cr measurements had good correspondence between sequences (intraclass correlation coefficients >0.88), while glutamate and related metabolites (Glu, Glu/Cr, Glx, Glx/Cr) demonstrated poor reliability. These findings emphasize the need to exercise caution when comparing glutamate measurements using different 1H-MRS sequences.

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