Newer spectral sequences have been developed to focus quantification of specific metabolites. In this study, measurements of glutamatergic metabolites in a human sample (N=178) were compared between two sequences, a standard TE-optimized PRESS sequence designed to capture broad spectral resonance and a 2-dimensional J-resolved PRESS sequence developed specifically for glutamate signal acquisition at the expense of broad resonance capability. Cho/Cr and NAA/Cr measurements had good correspondence between sequences (intraclass correlation coefficients >0.88), while glutamate and related metabolites (Glu, Glu/Cr, Glx, Glx/Cr) demonstrated poor reliability. These findings emphasize the need to exercise caution when comparing glutamate measurements using different 1H-MRS sequences.
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