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Abstract #2250

Rapid High-Resolution Metabolic Imaging of Stroke Using SPICE

Tianxiao Zhang1, Tianyao Wang2, Ziyu Meng1,3, Ke Xue1, Yudu Li3,4, Rong Guo3,4, Yibo Zhao3,4, Jun Liu2, Zheng Jin5, Xin Yu6, Zhi-Pei Liang3,4, and Yao Li1

1Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2Radiology department, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China, 3Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 4Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, 5Shanghai minhang hospital of Integrated traditional Chinese and Western Medicine Hospital, Shanghai, China, 6Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Disrupted metabolic activity is one of the most prominent pathophysiologic consequences of stroke. 1H-MRSI has been recognized as a powerful tool for metabolic imaging, but its clinical applications have been limited due to long scan time and poor spatial resolution. In this study, we investigate the feasibility of rapid high-resolution metabolic imaging of stroke using SPICE (SPectroscopic Imaging by exploiting spatiospectral CorrElation). We have successfully acquired metabolic maps from the whole brain at a nominal spatial resolution of 2.0×2.4×2.0 mm3 in a 5-min scan. Our experimental results clearly show metabolic alterations due to stroke.

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