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Abstract #2251

Feasibility of functional spectroscopy at a clinical 3T MR scanner

Petr Bednarik1, Alena Svatkova2, Dinesh Deelchand3, Rupert Lanzenberger4, and Wolfgang Bogner1

1High Field MR Center, Medical University of Vienna, Vienna, Austria, 2) Department of Medicine III, Clinical Division of Endocrinology and Metabolism, Medical University of Vienna, Vienna, Austria, 3Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 4Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria

Functional spectroscopy (fMRS) is capable of quantifying metabolite changes related to activation of brain energetic metabolism during sensory stimulation. Impaired energetic metabolism underlies pathophysiology of several neuropsychiatric diseases and therefore extension of fMRS to 3T clinical scanners is urgently needed. We evaluated feasibility of fMRS with advanced 1H-MRS based on semi-LASER localization highly optimized for 3T in 10 healthy volunteers. We observed significant changes of glutamate and glucose during short (12 min) paradigm of visual stimulation consistent with previous 7T reports. Thus, we demonstrated feasibility of 3T fMRS for clinical studies.

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