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Abstract #2252

Accurate Metabolite Quantification in the Presence Of Variable Lipids And Macromolecules: Two-Point Saturation Recovery MRS

Peter J Lally1, Alan Bainbridge2, Paolo Montaldo1, Vânia Oliveira1, Josephine Mendoza1, and Sudhin Thayyil1

1Imperial College London, London, United Kingdom, 2University College London Hospitals NHS Foundation Trust, London, United Kingdom

In various pathologies, changes in cerebral metabolite concentrations are accompanied by variations in the broader underlying lipid/macromolecular components. This introduces important biases in quantification at short echo times which, if unaddressed, undermine experiments which compare subjects with different injury severities.

Here we demonstrate the benefits of employing a simple two-point saturation recovery MRS experiment to reduce this bias introduced by pathology – in this case, taking the example of neonatal encephalopathy. This ability to accurately quantify spectra at all pathology severities is crucial for clinical trials, where biases would otherwise suppress sensitivity to important treatment effects.

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