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Abstract #2253

1H-NMR based metabolic profiles delineate the anticancer effect of vitamin C on hepatocellular carcinom cell

Caigui Lin1, Zhiliang Wei2, Jiyang Dong 1, and Zhong Chen1

1Department of Electronic Science, Xiamen University, Xiamen, China, 2Johns Hopkins University School of Medicine, Baltimore, MD, United States

Hepatocellular carcinoma (HCC) is a subtype of liver cancer with high worldwide prevalence and mortality. Its high recurrence rate and heterogeneity have challenged effectiveness of existing therapies. Numerous researchers explore the multifaceted benefits of Vitamin C (VC) in cancer treatments. In this study, we utilized the NMR-based metabolomics approach to systematically surrogate the molecular basis underlying the anticancer property of VC in HCC cell. Moreover, combination of VC with chemotherapeutic agent was tried to investigate synergetic effects in modulating metabolic profiles of cancer cells. Our results help to reveal the molecular basis of HCC treatment and may facilitate future clinical therapy designs.

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