Ten volunteers performed a Go/NoGo task during MRS acquisition at 7T to assess if event-related fMRS could detect dynamic glutamate changes during response inhibition. Metabolite spectra were acquired using a semiLASER sequence (to assess task-induced fluctuations in glutamate and lactate) and were interleaved with water-unsuppressed spectra (to assess the BOLD response-induced water linewidth changes). The voxel was placed in the dorsomedial prefrontal cortex. Although an fMRI pilot confirmed the voxel location, no significant differences in metabolite concentrations or water amplitude between NoGo and Go trials was detected.
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