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Abstract #2258

Behavior of the signal components of collagen solutions in vitro using UTE-MRI and MRS sequences

Tobias Winkler1, Petros Martirosian1, Erwin Schleicher2, Thomas Benkert3, and Fritz Schick1

1Section on Experimental Radiology, University Hospital of Tübingen, Tuebingen, Germany, 2Department of Internal Medicine, University Hospital of Tübingen, Tuebingen, Germany, 3Application Development, Siemens Healthcare GmbH, Erlangen, Germany

Collagen is a protein physiologically abundant in cartilage, tendons, and ligaments. Pathological processes in many organs might lead to accumulation of collagen in the extracellular space (eg, in hepatic, muscular or renal fibrosis), and non-invasive assessment of fibrotic changes in parenchyma is of high clinical interest. Ultrashort echo-time (UTE) sequences provide direct assessment of the fast decaying signals of collagen. In this work collagen solutions were analyzed in vitro with inversion recovery FID and spin echo spectroscopy sequences to get a better understanding of the different spectral components of collagen signals and their behavior using a 3T whole-body scanner.

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