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Abstract #2259

Detection of NAD+ in human brain is possible even at 3T and in spite of water pre-saturation when using a large voxel size

Maike Hoefemann1, Malgorzata Marjanska2, Edward J. Auerbach2, and Roland Kreis1

1University of Bern, Departments of Radiology and Biomedical Research, Bern, Switzerland, 2Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, United States

The detection of Nicotinamide adenine dinucleotide (NAD+) proved to be challenging in 1H Magnetic Resonance Spectroscopy, as standard water presaturation showed to lead to a strong suppression of NAD+ signals due to the polarization exchange between NAD+ and water. For the detection of such low-concentration metabolites, a high Signal-to-Noise-Ratio (SNR) is crucial. One possibility to increase the SNR is to choose a large voxel size (VS). In this study we show that optimizing acquisition parameters focusing on high SNR and increasing the VS to 75 cm3 allows the detection of NAD+ at 3T with a semi-LASER sequence despite water presaturation.

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