Abstract #2259

Detection of NAD+ in human brain is possible even at 3T and in spite of water pre-saturation when using a large voxel size

Maike Hoefemann¹, Malgorzata Marjanska², Edward J. Auerbach², and Roland Kreis¹

¹University of Bern, Departments of Radiology and Biomedical Research, Bern, Switzerland, ²Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, United States

The detection of Nicotinamide adenine dinucleotide (NAD⁺) proved to be challenging in ¹H Magnetic Resonance Spectroscopy, as standard water presaturation showed to lead to a strong suppression of NAD⁺ signals due to the polarization exchange between NAD⁺ and water. For the detection of such low-concentration metabolites, a high Signal-to-Noise-Ratio (SNR) is crucial. One possibility to increase the SNR is to choose a large voxel size (VS). In this study we show that optimizing acquisition parameters focusing on high SNR and increasing the VS to 75 cm³ allows the detection of NAD⁺ at 3T with a semi-LASER sequence despite water presaturation.

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