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Abstract #2270

Neurochemical measurement in the thalamus: a test-retest study at 7T

Song-I Lim1, Masoumeh Dehghani2, Rolf Gruetter1,3, and Lijing Xin3

1Laboratory for functional and metabolic imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 2Laboratory of functional and metabolic imaging, McGill University, Montreal, QC, Canada, 3Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

Thalamus has been known as a critical hub through which bidirectional neural signals are transmitted between cortical and subcortical region and its abnormalities are related to psychiatric disorders. The purpose of the study is to investigate the neurochemical profile in the thalamus and to evaluate the reliability of the measurement at 7T for the first time. In this study, 6 volunteers were scanned twice using semi-SPECIAL sequence. 10 metabolites were detected including Glu, GABA, and GSH with accuracy. The average CoV of the metabolites was 8 ± 5%. This study provides a reference for future neurological studies in the thalamus.

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