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Abstract #2269

Modulation of brain oxidative and glycolytic metabolisms using a finger tapping task: an ASL-fMRI and fMRS study

Yohan Boillat1, Lijing Xin2, Olivier Reynaud2,3, Wietske van der Zwaag2,4, and Rolf Gruetter1,2

1Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 2Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 3Fondation Campus Biotech Geneva, Geneva, Switzerland, 4Spinoza Centre for Neuroimaging, Amsterdam, Netherlands

Using [Lac] and [Glu] as markers of glycolytic and oxidative metabolisms, respectively, we investigated the involvement of each of these pathways during a finger tapping task at different frequencies. We measured BOLD and CBF data and metabolite concentrations at 7T. BOLD and CBF signals increased for increasing finger tapping frequencies as well as [Lac]. The [Glu] changes were smaller and, with the current number of participants, did not follow the same trend.

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