Abstract #2268

The association between plasma and brain glutamine and glutamate in healthy volunteers probed by LC-MS and 1H-MRS

Naoto Sato¹, Yuhei Takado², Yuta Kanbe¹, Moyoko Tomiyasu¹, Lijing Xin³, Jamie Near⁴, Kohki Yoshikawa⁵, Tatsuya Higashi¹, Tetsuya Suhara⁶, Makoto Higuchi⁶, and Takayuki Obata¹

¹Department of Molecular Imaging and Theranostics, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, ²Department of Functional Brain Imaging Research, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, ³CIBM, École polytechnique fédérale de Lausanne, Lausanne, Switzerland, ⁴Department of Psychiatry, McGill University, Montreal, QC, Canada, ⁵Department of Radiological Sciences, Komazawa University, Tokyo, Japan, ⁶National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan

The present study aimed to evaluate the association between the plasma and brain glutamine (Glu) and glutamate (Gln) using proton magnetic resonance spectroscopy (¹H-MRS) and liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-MS), respectively, in 20 participants. A positive correlation between Gln to tCr (creatine +phosphocreatine) ratio in the posterior cingulate gyrus (PCC) and the plasma Gln indicates that Gln can be transferred effectively by Gln transporters at the blood-brain barrier (BBB). No correlation of Gln in the cerebellum (Cbll) may be attributed to either regional difference of Gln transport or lower reproducibility of the measurements in Cbll than in PCC.

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