Abstract #2267

Initial observations of position-dependent B0 distortions in a concurrent TMS/MRS phantom experiment

Leo Sporn^1,2, Erin L MacMillan^3,4,5, Ruiyang Ge⁶, Afifa Humaira⁶, Laura L Barlow⁴, Cornelia Laule^1,2,7, and Fidel Vila-Rodriguez⁶

¹Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, ²International Collaboration on Repair Discoveries, Vancouver, BC, Canada, ³Philips Healthcare, Markham, ON, Canada, ⁴Radiology, University of British Columbia, Vancouver, BC, Canada, ⁵Mechatronic Systems Engineering, Simon Fraser University, Vancouver, BC, Canada, ⁶Psychiatry, Non-Invasive Neurostimulation Therapies, University of British Columbia, Vancouver, BC, Canada, ⁷Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

There is interest in using MRS to study the effects of transcranial magnetic stimulation (TMS), but a major challenge is B₀ inhomogeneities introduced by the TMS coil. Phantom work showed increasing B₀ inhomogeneity as the MRS voxel was moved closer to the TMS coil. Distortions in the metabolite signals included increased noise fluctuations and spectral linewidth by ~50% when the voxel center was < 6cm away from the TMS coil B₀ inhomogeneity effects were similar whether the TMS coil was pulsing prior to the PRESS sequence or not. Our results suggest TMS/MRS may be able to resolve spectra in vivo.

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