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Abstract #2266

Impact of Cannula Implantation on Neurochemical Profile in juvenile rat model for ADHD @ 11.7T

Alireza Abaei1, Dinesh K Deelchand2, Francesca Rizzo3, Tobias M. Böckers 3, and Volker Rasche4

1Core Facility Small Animal Imaging, University Ulm, Ulm, Germany, 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 3Institute of Anatomy and Cell Biology, Ulm University, Ulm, Germany, 4Core Facility Small Animal Imaging, Ulm University, Ulm, Germany

To detect subtle changes in the neurometabolite concentrations by MRS, it is of utmost importance that the dominant contribution to the metabolic changes, is caused by the pathology of interest itself. Many studies involve surgery to interface e.g. cannulas to the brain. We investigate the impact of implanting an intracerebral cannula on the striatal neurochemical profile. MRS of the striatum from both hemisphere was performed 14d after surgery. A significant reduction of almost all metabolites was observed in the hemisphere with cannulation as well as contralateral side, indicating a dominant impact of the surgery, which might impact the sensitivity of MRS for quantification of pathologic processes.

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