Abstract #2274

Distribution pattern of neurotransmitters and antioxidants in human brain: a 1H-MRS study at 7 T

Jun-ichiro Enmi^1,2, Ikuhiro Kida^1,2, Seishi Itoi², Tetsuya Shimokawa^1,2, Noriaki Hattori^2,3,4, and Yoshichika Yoshioka^1,2,5

¹Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan, ²Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology (NICT), Osaka, Japan, ³Endowed Research Department of Clinical Neuroengineering, Global Center for Medical Engineering and Informatics, Osaka University, Osaka, Japan, ⁴Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan, ⁵Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan

The concentrations of some neurotransmitters (N–acetylaspartylglutamate (NAAG), glutamate (Glu), and γ-aminobutyric acid (GABA)) and some antioxidants (glutathione (GSH), ascorbic acid (Asc), and taurine (Tau)) were measured in human brain gray and white matters by using ¹H-MRS at 7 T. The distribution patterns of NAAG, Glu, and GABA were completely different from each other. The distribution patterns of the antioxidants had a relatively similar tendency. The concentrations of Asc and Tau were significantly higher in gray matters than in white matters, although there was no significant difference in GSH concentration between the gray and white matter.

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