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Abstract #2274

Distribution pattern of neurotransmitters and antioxidants in human brain: a 1H-MRS study at 7 T

Jun-ichiro Enmi1,2, Ikuhiro Kida1,2, Seishi Itoi2, Tetsuya Shimokawa1,2, Noriaki Hattori2,3,4, and Yoshichika Yoshioka1,2,5

1Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan, 2Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology (NICT), Osaka, Japan, 3Endowed Research Department of Clinical Neuroengineering, Global Center for Medical Engineering and Informatics, Osaka University, Osaka, Japan, 4Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan, 5Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Osaka, Japan

The concentrations of some neurotransmitters (N–acetylaspartylglutamate (NAAG), glutamate (Glu), and γ-aminobutyric acid (GABA)) and some antioxidants (glutathione (GSH), ascorbic acid (Asc), and taurine (Tau)) were measured in human brain gray and white matters by using 1H-MRS at 7 T. The distribution patterns of NAAG, Glu, and GABA were completely different from each other. The distribution patterns of the antioxidants had a relatively similar tendency. The concentrations of Asc and Tau were significantly higher in gray matters than in white matters, although there was no significant difference in GSH concentration between the gray and white matter.

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