Abstract #2275

Potential Celiac disease (CeD) patients may serve as pre-clinical model to understand pathogenesis of Celiac Disease: A NMR metabonomics approach

Deepti Upadhyay¹, Naranamangalam R Jagannathan¹, Govind K Makharia ², Siddharth Datta Gupta³, Prasenjit Das³, and Uma Sharma¹

¹Department of NMR & MRI Facility, All India Institute of Medical Sciences (AIIMS), New Delhi, India, ²Department of Gastroenterology and human Nutrition, All India Institute of Medical Sciences, New Delhi, India, ³Department of Pathology, All India Institute of medical sciences, New Delhi, India

Potential celiac disease (CeD) patients have positive CeD associated antibodies (anti-tissue tansglutaminase antibodies) and HLA-DQ2 and/or HLA-DQ8 genotype but no intestinal inflammation. NMR based metabonomic study of blood plasma of potential CeD patients demonstrated a distinct metabolic fingerprint characterized by raised histidine and proline in comparison to healthy controls. The changes in histidine suggested compromised cytoprotective mechanism while elevated arginine level indicated altered functioning of intestinal cells in potential CeD. These altered metabolic activities could be the initial event that precede the pathogenesis of CeD and may contribute to intestinal inflammation which results in villous atrophy.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.