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Abstract #2276

Role of combining NMR metabolomics data of intestinal mucosal biopsies, blood plasma and urine for determining biomarker/s for Celiac Disease (CeD)

Deepti Upadhyay1, Prasenjit Das2, Siddharth Datta Gupta2, Govind K Makharia 3, Naranamangalam R Jagannathan1, and Uma Sharma1

1Department of NMR & MRI Facility, All India Institute of Medical Sciences (AIIMS), New Delhi, India, 2Department of Pathology, All India Institute of medical sciences, New Delhi, India, 3Department of Gastroenterology and human Nutrition, All India Institute of Medical Sciences, New Delhi, India

NMR based metabonomics of small intestinal mucosal biopsies, blood plasma and urine samples from same set of patients demonstrated the underlying biochemical abnormalities and biomarker/s for celiac disease (CeD). Intestinal mucosa of CeD patients had higher levels of proline and allantoin while lower glycine, histidine and GPC compared to controls. Metabolome of blood plasma of CeD patients showed significantly higher concentration of proline, arginine and β-hydroxybutyrate while urine had higher proline, allantoin and β-hydroxybutyrate compared to healthy controls. These findings indicated metabolic abnormalities associated with villous atrophy seen in CeD and suggested proline, arginine and allantoin may serve as biomarker/s.

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