Meeting Banner
Abstract #2281

Comparison of LCModel fitting of HRMAS spectra acquired from malignant glioma tissue using free induction decay and Carr-Purcell-Meiboom-Gill pulse sequences

Selin Ekici1, Ren Geryak1, and Candace C Fleischer1

1Department of Radiology & Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States

Gliomas are a class of aggressive brain tumors with a low survival rate. New biomarkers are needed to monitor tumor progression and response to treatment. Our goal was to compare the effectiveness of operator-independent LCModel analysis for HRMAS NMR spectra acquired from histologically confirmed glioma tissue (n=14) using both FID and CPMG pulse sequences. The CRLBs of lactate and myo-inositol were significantly lower for spectra acquired with the CPMG compared to the FID sequence. Relevant glioma metabolites were quantified with LCModel from most spectra acquired with CPMG but not FID.

This abstract and the presentation materials are available to members only; a login is required.

Join Here