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Abstract #2282

Tumor COX-2 overexpression in triple negative breast cancer alters spleen metabolism

James D Barnett1, Santosh K Bharti1, Balaji Krishnamachary1, Flonne Wildes1, Yelena Mironchik1, Marie-France Penet1,2, and Zaver Bhujwalla 1,2,3

1Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD, United States, 2Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, United States, 3Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Cyclooxygenase-2 (COX-2) is an inducible enzyme that mediates the inflammatory response of cells. COX-2 overexpression is associated with poor prognosis in breast cancers. Here we have investigated the effect of tumor COX-2 overexpression on spleen metabolism, using 1H magnetic resonance spectroscopy (MRS), as part of an overall focus on understanding the impact of cancers on inducing metabolic changes in critical organs. We focused on the spleen since it plays a critical role in the immune response and detected distinct differences in glutamate and lactate with COX-2 overexpression.

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