Abstract #2293

Alteration in 1H MRS metabolites in the rat spinal cord after experimental craniospinal irradiation

Petra Hnilicová¹, Soňa Bálentová², Dagmar Kalenská ³, Eva Hajtmanová ⁴, Peter Murín ⁴, Michal Bittšanský¹, Marian Adamkov ², Ján Lehotský³, and Dušan Dobrota ³

¹Division of Neurosciences at Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia, ²Institute of Histology and Embryology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia, ³Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia, ⁴Department of Radiotherapy and Oncology, University Hospital Martin, Martin, Slovakia

We investigated the metabolic effect of a clinically relevant craniospinal irradiation on the rat spinal cord using ¹H MRS at 7T. Hundred days after the fractionated irradiation performed by radioactive isotope ⁶⁰Co (16Gy in 2 fractions), irradiated and sham-irradiated animals underwent in vivo ¹H MRS examination. Spinal cord spectra were measured by SVS sequence with voxel size of 3.5x2x7.5mm³. In spinal cord of irradiated animals was confirmed significantly reduced tNAA/tCr and increased tCho/tCr ratio, both showing demyelination and inflammatory processes. It seems that in vivo ¹H MRS of spinal cord could be useful for radiation therapy monitoring.

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