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Abstract #2294

Quantifying the CEST@2ppm from 5-pool Lorentzian fitting in the substantia nigra of acute MPTP mouse models at 7 Tesla

Guojing Wei1 and Yanqiu Feng1

1Southern Medical University, Guangzhou, China

Non-invasive and quantifiable diagnosis of Parkinson’s disease is an ongoing challenge for researchers. In this study, we worked on the CEST signal at 2ppm (CEST@2ppm) in the substantia nigra of acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse models at three different time points including pre and 3rd day, 10th day after treatment. CEST@2ppm after 5-pool lorentzian fitting showed a statistically significant difference after MPTP injection and metrics based on this fitting model ( MTRrex and AREX) also indicated positive correlation of CEST@2ppm with the SN damages while the statistic difference of 3rd and 10th day was not significant. This quantifying CEST signal may reflect the pathological mechanism of PD in SN.

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