Abstract #2296

Water T2 is altered with hepatic lipid fraction at 3 Tesla

Pandichelvam Veeraiah^1,2, Julian Mevenkamp¹, Ine Telgenkamp³, Nynke Simons³, Martijn Brouwers³, Joachim E Wildberger¹, Patrick Schrauwen², Vera B Schrauwen-Hinderling^1,2, and Lucas Lindeboom^1,2

¹Department of Radiology, Maastricht University Medical Centre, Maastricht, Netherlands, ²Nutrition and Movement Sciences, NUTRIM school for Nutrition and Translational Research in Metabolism, Maastricht, Netherlands, ³Internal medicine, Maastricht University Medical Centre, Maastricht, Netherlands

¹H-MRS is extensively used to measure the hepatic lipid content. Conventionally, the water resonance is used as an internal reference, thereby assuming a constant T₂ decay of water across individuals to estimate absolute hepatic lipid content. However, the T₂ values reported in literature for 3T vary widely, which might be due to different subject populations and/or other methodological discrepancies. The purpose of this study was to measure T₂ of water in a group of subjects with a wide range of hepatic lipid content and to evaluate whether there is a dependence of water T₂ relaxation times and hepatic lipid fraction.

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