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Abstract #2296

Water T2 is altered with hepatic lipid fraction at 3 Tesla

Pandichelvam Veeraiah1,2, Julian Mevenkamp1, Ine Telgenkamp3, Nynke Simons3, Martijn Brouwers3, Joachim E Wildberger1, Patrick Schrauwen2, Vera B Schrauwen-Hinderling1,2, and Lucas Lindeboom1,2

1Department of Radiology, Maastricht University Medical Centre, Maastricht, Netherlands, 2Nutrition and Movement Sciences, NUTRIM school for Nutrition and Translational Research in Metabolism, Maastricht, Netherlands, 3Internal medicine, Maastricht University Medical Centre, Maastricht, Netherlands

1H-MRS is extensively used to measure the hepatic lipid content. Conventionally, the water resonance is used as an internal reference, thereby assuming a constant T2 decay of water across individuals to estimate absolute hepatic lipid content. However, the T2 values reported in literature for 3T vary widely, which might be due to different subject populations and/or other methodological discrepancies. The purpose of this study was to measure T2 of water in a group of subjects with a wide range of hepatic lipid content and to evaluate whether there is a dependence of water T2 relaxation times and hepatic lipid fraction.

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