Abstract #2302

Design and validation of an MRI-based oxygen sensor for a cervical cancer clinical trial

Gregory J. Ekchian¹, Junichi Tokuda², Brian Barnes¹, Robert Cormack³, Larissa Lee³, and Michael Cima^1,4

¹Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States, ²Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States, ³Department of Radiation Oncology, Brigham and Women's Hospital, Boston, MA, United States, ⁴Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States

Many cancer patients experience lower survival rates if they have less well oxygenated tumors. Lower tumor oxygen levels can lead to a reduced effectiveness of radiation therapy. The ability to overcome this radiotherapy resistance has been severely limited by the lack of a clinically compatible quantitative oxygen sensing technology. We report the design and validation of a silicone-based oxygen sensor measured with MRI for an approved human clinical trial in patients with cervical cancer. The sensor has been validated for compatibility with the clinical workflow and is specifically designed to achieve the endpoints of the trial.

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