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Abstract #2303

Multiparamter MRI Investigation of High-Grade Glioma Response to CAR T Cell Immunotherapy

Harshan Ravi1, Olya Stringfield2, Gustavo De Leon3, Sandra Johnston4, Christine E Brown5, Kristin R Swanson3, Robert A Gatenby6, and Natarajan Raghunand1

1Department of cancer physiology, Moffitt Cancer research center, Tampa, FL, United States, 2Irat Shared service, Moffitt Cancer research center, Tampa, FL, United States, 3Mathematical NeuroOncology Lab Precision Neurotherapeutics innovation program, Mayo clinic, Phoenix, AZ, United States, 4Department of Radiology, University of Washington, Seattle, WA, United States, 5Department of Cancer Immunotherapy and Tumor Immunology, City of Hope Beckman Research Institute and Medical Center, Duarte, CA, United States, 6Department diagnostic and interventional radiology, Moffitt Cancer research center, Tampa, FL, United States

Immunotherapy is gaining interest for treatment of even poorly immunogenic cancers like gliomas. Pseudo-progression and pseudo-response are frequently noted on standard of care MRI in glioma patients receiving immunotherapy. We present a "Habitat" imaging approach to objectively follow response to CAR T cell therapy of glioma.

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