Abstract #2303

Multiparamter MRI Investigation of High-Grade Glioma Response to CAR T Cell Immunotherapy

Harshan Ravi¹, Olya Stringfield², Gustavo De Leon³, Sandra Johnston⁴, Christine E Brown⁵, Kristin R Swanson³, Robert A Gatenby⁶, and Natarajan Raghunand¹

¹Department of cancer physiology, Moffitt Cancer research center, Tampa, FL, United States, ²Irat Shared service, Moffitt Cancer research center, Tampa, FL, United States, ³Mathematical NeuroOncology Lab Precision Neurotherapeutics innovation program, Mayo clinic, Phoenix, AZ, United States, ⁴Department of Radiology, University of Washington, Seattle, WA, United States, ⁵Department of Cancer Immunotherapy and Tumor Immunology, City of Hope Beckman Research Institute and Medical Center, Duarte, CA, United States, ⁶Department diagnostic and interventional radiology, Moffitt Cancer research center, Tampa, FL, United States

Immunotherapy is gaining interest for treatment of even poorly immunogenic cancers like gliomas. Pseudo-progression and pseudo-response are frequently noted on standard of care MRI in glioma patients receiving immunotherapy. We present a "Habitat" imaging approach to objectively follow response to CAR T cell therapy of glioma.

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