Flux via the pentose phosphate pathway (PPP) is typically upregulated in tumor cells. Imaging this upregulation could therefore help in monitoring tumor development and response to treatment. A previous study presented the use of hyperpolarized δ-[1-13C]gluconolactone to detect flux through PPP by monitoring its conversion to 6-phospho-[1-13C]gluconate in isolated perfused livers. Here, we demonstrate that HP δ-[1-13C]gluconolactone can also be used to monitor PPP activity in healthy brain and in gliomas, and that the ratio of HP 6-phospho-[1-13C]gluconate to 6-phospho-δ-[1-13C]gluconolactone is significantly higher in tumor regions compared to healthy brain.
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