We determined the biodistribution of adoptively transferred primary T-cells in naïve mice to create a basis for quantifying adoptively transferred modified T-cells in mice cancer models, using PET and MRI cell labeling techniques simultaneously. Separate populations of T-cells were labeled with either a PET (89Zr) or an MRI label (ferumoxytol), and were injected intravenously into mice together. Animals underwent simultaneous PET/MRI imaging up to 5 days following cell injection in an MR Solutions 7 Tesla scanner with a PET camera. We looked at two models: primary mouse T-cells in naïve Balb/c mice and primary human T-cells in naïve NSG.
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