Pancreatic cancer (PDAC) is a highly aggressive malignancy, displaying poor response to the frontline chemotherapeutics. PDAC cells undergo cellular reprograming to meet their bioenergetic and biosynthetic demands, with glycolytic shift emerging as the primary metabolic hallmark of carcinogenesis. Bitter melon juice (BMJ) is a widely consumed vegetable in Asia; recent studies have reported an increased AMPK phosphorylation and activation in BMJ-treated tumor xenografts. Here, we report on an inhibition of lactate export in PANC1 cells upon BMJ treatment, leading to acidification and cell death mediated by decreased transporter expression of GLUT1 and MCT4, both in vitro and in vivo.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords