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Abstract #2307

13C Metabolomic and Fluxomic Study of Human Melanoma Metabolic Network in vivo

Alexander A. Shestov1, Seung-Cheol Lee1, Kavindra Nath1, Jeff Roman1, Clementina Mesaros2, David A. Nelson2, Dennis Leeper3, Ian A. Blair2, and Jerry D. Glickson1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2University of Pennsylvania, Philadelphia, PA, United States, 3Thomas Jefferson University, Philadelphia, PA, United States

Information from 13C isotopomers, which appear as multiplets in 13C spectra can be measured and quantified in vivo. Using this additional information alone with extended melanoma tumor bionetwork model has enable simultaneous fitting of experimental dynamic isotopomer turnover curves and evaluation of metabolic parameters and fluxes

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