Abstract #2307

13C Metabolomic and Fluxomic Study of Human Melanoma Metabolic Network in vivo

Alexander A. Shestov¹, Seung-Cheol Lee¹, Kavindra Nath¹, Jeff Roman¹, Clementina Mesaros², David A. Nelson², Dennis Leeper³, Ian A. Blair², and Jerry D. Glickson¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²University of Pennsylvania, Philadelphia, PA, United States, ³Thomas Jefferson University, Philadelphia, PA, United States

Information from 13C isotopomers, which appear as multiplets in 13C spectra can be measured and quantified in vivo. Using this additional information alone with extended melanoma tumor bionetwork model has enable simultaneous fitting of experimental dynamic isotopomer turnover curves and evaluation of metabolic parameters and fluxes

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