Abstract #2309

Towards a Small Molecule GDPD6 Inhibitor: Investigating Dipyridamole via 1H HRMRS and Computational Studies

Caitlin Tressler¹, Kanchan Sonkar¹, and Kristine Glunde^1,2

¹The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

We are studying the role of GDPD6 in breast cancer, as well as its potential as a therapeutic target. GDPD6 silencing experiments showed decreased invasion and migration in breast cancer cells. There is currently no small molecule inhibitor for GDPD6. We have identified dipyridamole as potential GDPD6 inhibitor, which can be used both in the lab and potentially in the clinic. We are using a combination of ¹H MRS and computational studies to determine how dipyridamole inhibits GDPD6 to evaluate its potential as an inhibitor and identify other potential small molecule inhibitors of GDPD6.

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