Abstract #2310

Time evolution of extracellular pH with BIRDS in a rabbit model of human liver cancer

Daniel Coman¹, Lynn Jeanette Savic¹, Isabel Schobert¹, John Walsh², Lucas Christoph Adam¹, Nina Tritz¹, MingDe Lin^1,3, Julius Chapiro¹, Albert John Sinusas^1,4, Todd Constable¹, Douglas Rothman^1,2, James Duncan^1,2, Fahmeed Hyder^1,2, and Dana Peters¹

¹Radiology & Biomedical Imaging, Yale University, New Haven, CT, United States, ²Biomedical Engineering, Yale University, New Haven, CT, United States, ³Visage Imaging, Inc., San Diego, CA, United States, ⁴Cardiovascular Medicine, Yale University, New Haven, CT, United States

Here we report extracellular pH (pH_e) mapping with BIRDS using TmDOTP^5- in normal and VX2 tumors in rabbit liver tissue. Transarterial chemoembolization (TACE) was performed and the rabbits were scanned without TACE, or at 1 day and 2 weeks post TACE. The pH_e maps show lower pH_e in tumor and tumor edge compared to normal liver. Tumor acidity prior to TACE remain at 1 day post TACE, but it is almost normalized at 2 weeks post TACE. The ability to measure pH_e in a translational model and compare it with “normal” tissue improves tumor detection and monitoring of tumor treatment.

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