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Abstract #2310

Time evolution of extracellular pH with BIRDS in a rabbit model of human liver cancer

Daniel Coman1, Lynn Jeanette Savic1, Isabel Schobert1, John Walsh2, Lucas Christoph Adam1, Nina Tritz1, MingDe Lin1,3, Julius Chapiro1, Albert John Sinusas1,4, Todd Constable1, Douglas Rothman1,2, James Duncan1,2, Fahmeed Hyder1,2, and Dana Peters1

1Radiology & Biomedical Imaging, Yale University, New Haven, CT, United States, 2Biomedical Engineering, Yale University, New Haven, CT, United States, 3Visage Imaging, Inc., San Diego, CA, United States, 4Cardiovascular Medicine, Yale University, New Haven, CT, United States

Here we report extracellular pH (pHe) mapping with BIRDS using TmDOTP5- in normal and VX2 tumors in rabbit liver tissue. Transarterial chemoembolization (TACE) was performed and the rabbits were scanned without TACE, or at 1 day and 2 weeks post TACE. The pHe maps show lower pHe in tumor and tumor edge compared to normal liver. Tumor acidity prior to TACE remain at 1 day post TACE, but it is almost normalized at 2 weeks post TACE. The ability to measure pHe in a translational model and compare it with “normal” tissue improves tumor detection and monitoring of tumor treatment.

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