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Abstract #2311

Toward Quantitative MRI Parameter Mapping of Triple Negative Breast Cancer Patient-Derived Xenographs: The Challenge of Tumor Heterogeneity

Xia Ge1, John A Engelbach1, James D Quirk1, Larry G Bretthorst1, Joel R Garbow1,2, and Joseph JH Ackerman1,2,3

1Departments of Radiology, Washington University, St Louis, MO, United States, 2Alvin J. Siteman Cancer Center, Washington University, St Louis, MO, United States, 3Department of Chemistry, Washington University, St Louis, MO, United States

Triple negative breast cancer patient-derived xenographs were implanted in the 4th abdominal mammary fat pads of mice enrolled in a ~60 minute, multi-contrast, same-day (morning vs. afternoon), test-retest MRI protocol. Quantitative T1, T2, and ADC maps were acquired. Parameter distributions were characterized by standard statistical measures (mean, median, standard deviation, skewness, and kurtosis) and a Bayesian implementation of the maximum-entropy method-of-moments density function. TNBC PDX T2 maps were found to be markedly more robust to test-retest assessment compared to T1 and ADC maps. These results will inform studies employing MRI assessment of TNBC PDX response to docetaxel/carboplatin therapy.

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