Abstract #2312

OE-MRI, DCE-MRI and DWI provide complementary response evaluation in patients with rectal cancer treated with chemoradiotherapy

Ross A Little¹, Anubhav Datta², Adam K Featherstone¹, Yvonne Watson¹, Susan Cheung¹, Lucy Buckley³, Mark P Saunders³, Geoff JM Parker^1,4, and James PB O'Connor^1,2,5

¹Quantitative Biomedical Imaging Laboratory, University of Manchester, Manchester, United Kingdom, ²Department of Radiology, Christie Hospital, Manchester, United Kingdom, ³Department of Clinical Oncology, Christie Hospital, Manchester, United Kingdom, ⁴Bioxydyn Ltd, Manchester, United Kingdom, ⁵Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom

Biomarkers derived from functional MRI have potential to monitor response to therapy and stratify patient care. In this study of 22 patients with rectal cancer we evaluated the relative merits of using OE-MRI, DCE-MRI and DWI biomarkers to assess response to chemoradiotherapy. We show that OE-MRI is feasible in rectal cancer tumours and provides complementary information to that measured by DWI and DCE-MRI. Data suggests that OE-MRI may be useful as a pharmacodynamic tool to identify hypoxia modification as this was present by day 14, but not at day 7 into therapy.

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