Current radiology can detect small lung cancer (LuCa) lesions. However, their high costs coupled with their unproven efficacies as screening tools have prevented their use in annual screening protocols to detect LuCa at early and clinically asymptomatic stages. A simple and non-invasive screening technique, preferably a blood test, is needed to control the disease. Here we present results from mass spectrometry imaging that can produce localized “microscopic” maps of cancer metabolomic distributions revealed by high-resolution magic angle spinning magnetic resonance spectroscopy (HRMAS MRS), and can further assist establish blood serum LuCa biomarkers from analyses of human LuCa tissue-serum paired samples.
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