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Abstract #2319

Interrogations of Human Lung Cancer Metabolomics Measured from Intact Tissue Magnetic Resonance Spectroscopy with Mass Spectrometry Imaging

Stephen J Eyles1, Mari Mino-Kenudson2, Igor A Kaltashov1, Richard W Vachet1, Yiying Zhang3, Kristen Sikora1, Cedric Bobst1, David C Christiani4, and Leo L Cheng5

1University of Massachusetts Amherst, Amherst, MA, United States, 2MGH/Harvard Medical School, Combridge, MA, United States, 3MGH/Harvard Medical School, Charlestown, MA, United States, 4Harvard School of Public Health, Boston, MA, United States, 5Radiology and Pathlogy, MGH/Harvard Medical School, Charlestown, MA, United States

Current radiology can detect small lung cancer (LuCa) lesions. However, their high costs coupled with their unproven efficacies as screening tools have prevented their use in annual screening protocols to detect LuCa at early and clinically asymptomatic stages. A simple and non-invasive screening technique, preferably a blood test, is needed to control the disease. Here we present results from mass spectrometry imaging that can produce localized “microscopic” maps of cancer metabolomic distributions revealed by high-resolution magic angle spinning magnetic resonance spectroscopy (HRMAS MRS), and can further assist establish blood serum LuCa biomarkers from analyses of human LuCa tissue-serum paired samples.

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