Glioblastoma (GBM) induces both vasogenic edema and extensive tumor cells infiltration, both of which present with similar appearance and not be differentiated on conventional MRI. To distinguish between these infiltrative tumor and vasogenic edema components within the nonenhancing lesion area using novel techniques thus holds great clinical importance. Oxygen-enhanced MRI may directly reflect tissue oxygenation, has shown promising applications in the measurement of hypoxia or radiation-induced necrosis. Therefore, in this study we explored the possibility to differentiate vasogenic edema from infiltrative tumor in patients with GBM using oxygen-enhanced MRI. The results showed significant more negative ΔR1 levels (p < 0.05) were observed in the infiltrative tumor area compared to those in the vasogenic edema and tumor site. Oxygen-enhanced MR imaging has thus the potential to differentiate infiltrative tumor from vasogenic edema in glioblastoma.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords